John Dunlop Selected Research

Schizophrenia (Dementia Praecox)

3/2016	State-dependent alterations in sleep/wake architecture elicited by the M4 PAM VU0467154 - Relation to antipsychotic-like drug effects.
1/2016	Gene-Tailored Treatments for Brain Disorders: Challenges and Opportunities.
2/2015	Schizophrenia drug discovery and development in an evolving era: are new drug targets fulfilling expectations?
10/2014	Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents.
11/2012	N-[5-(5-fluoropyridin-3-yl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): a medicinal chemistry effort toward an α7 nicotinic acetylcholine receptor agonist preclinical candidate.
1/2012	5-HT(2C) agonists as therapeutics for the treatment of schizophrenia.
12/2011	Preclinical assessment of an adjunctive treatment approach for cognitive impairment associated with schizophrenia using the alpha7 nicotinic acetylcholine receptor agonist WYE-103914/SEN34625.
6/2011	Aligning strategies for using EEG as a surrogate biomarker: a review of preclinical and clinical research.
1/2010	Neuronal nicotinic acetylcholine receptors - targets for the development of drugs to treat cognitive impairment associated with schizophrenia and Alzheimer's disease.
7/2009	SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist.

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John Dunlop Research Topics

Disease

15	Schizophrenia (Dementia Praecox) 03/2016 - 02/2006
8	Cognitive Dysfunction 02/2015 - 05/2009
7	Alzheimer Disease (Alzheimer's Disease) 11/2012 - 06/2008
5	Parkinson Disease (Parkinson's Disease) 06/2014 - 09/2008
4	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2017 - 11/2004
4	Mental Disorders (Mental Disorder) 01/2016 - 11/2007
3	Pain (Aches) 06/2011 - 05/2007
2	Disease Progression 01/2017 - 01/2013
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2017 - 03/2003
2	Status Epilepticus (Complex Partial Status Epilepticus) 01/2016 - 03/2015
2	Nervous System Diseases (Neurological Disorders) 11/2014 - 10/2004
2	Neuroblastoma 02/2014 - 03/2006
2	Weight Gain 01/2012 - 02/2006
2	Central Nervous System Diseases (CNS Diseases) 06/2011 - 02/2006
2	Ischemia 09/2008 - 06/2005
2	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive) 06/2007 - 11/2006
1	Kabuki syndrome 03/2021
1	Intellectual Disability (Idiocy) 03/2021
1	Fragile X Syndrome (Martin Bell Syndrome) 01/2017
1	Proteostasis Deficiencies 01/2017
1	Frontotemporal Dementia (Semantic Dementia) 01/2017
1	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 06/2011
1	Lactic Acidosis 09/2008
1	Brain Ischemia (Cerebral Ischemia) 09/2008
1	Polydipsia 06/2007
1	Obesity 11/2006
1	Migraine Disorders (Migraine) 11/2006
1	Erectile Dysfunction 11/2006
1	Body Weight (Weight, Body) 02/2006
1	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 11/2004
1	Heart Valve Diseases (Valvular Heart Disease) 12/2002
1	Carcinoid Tumor (Carcinoid) 12/2002

Drug/Important Bio-Agent (IBA)

7	Pharmaceutical PreparationsIBA 02/2015 - 10/2004
6	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 05/2014 - 06/2008
4	alpha7 Nicotinic Acetylcholine ReceptorIBA 12/2011 - 03/2009
3	Glutamic Acid (Glutamate)FDA Link 01/2016 - 03/2003
3	Antipsychotic Agents (Antipsychotics)IBA 02/2015 - 12/2011
3	5-HT2C Serotonin ReceptorIBA 11/2007 - 11/2006
2	Proteins (Proteins, Gene)FDA Link 01/2017 - 06/2014
2	LigandsIBA 04/2013 - 07/2007
2	Cholinergic Agents (Cholinergics)IBA 07/2009 - 08/2007
2	1,2,3,4,8,9,10,10a- octahydro- 7bH- cyclopenta(b)(1,4)diazepino(6,7,1hj)indoleIBA 06/2007 - 11/2006
2	Serotonin (5 Hydroxytryptamine)IBA 02/2006 - 12/2002
1	MethyltransferasesIBA 03/2021
1	Histones (Histone)IBA 03/2021
1	Lysine (L-Lysine)FDA Link 03/2021
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2017
1	Biomarkers (Surrogate Marker)IBA 01/2017
1	DNA-Binding Proteins (DNA Binding Protein)IBA 01/2017
1	Aminobutyrates (Aminobutyric Acid)IBA 01/2017
1	Protein AggregatesIBA 01/2017
1	Dizocilpine Maleate (Dizocilpine)IBA 03/2016
1	5- amino- 3,4- dimethyl- N- (4- ((trifluoromethyl)sulfonyl)benzyl)thieno(2,3- c)pyridazine- 6- carboxamideIBA 03/2016
1	Hypnotics and Sedatives (Sedatives)IBA 03/2016
1	Clozapine (Clozaril)FDA LinkGeneric 03/2016
1	Glutamate Receptors (Glutamate Receptor)IBA 03/2016
1	N-Methylaspartate (NMDA)IBA 03/2016
1	4-Aminopyridine (4 Aminopyridine)FDA Link 01/2016
1	Alanine (L-Alanine)FDA Link 03/2015
1	Dopamine D2 Receptors (Dopamine D2 Receptor)IBA 02/2015
1	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 10/2014
1	Mutant Proteins (Protein, Mutant)IBA 06/2014
1	ceramide glucosyltransferaseIBA 06/2014
1	GlycosphingolipidsIBA 06/2014
1	SynucleinsIBA 06/2014
1	Leucine (L-Leucine)FDA Link 02/2014
1	Amino Acids FDA Link 02/2014
1	IsotopesIBA 02/2014
1	PhosphopeptidesIBA 02/2014
1	Phosphotransferases (Kinase)IBA 02/2014
1	alpha-SynucleinIBA 01/2013
1	PrionsIBA 01/2013
1	vabicaserinIBA 01/2012
1	1- (6- (4- fluorophenyl)pyridin- 3- yl)- 3- (4- piperidin- 1- ylbutyl)ureaIBA 12/2011
1	N,N'-dibenzhydrylethane-1,2-diamine dihydrochlorideIBA 07/2011
1	metabotropic glutamate receptor 7IBA 07/2011
1	5-morpholin-4-ylpentanoic acid (4-pyridin-3-ylphenyl)amideIBA 05/2009
1	Acid Sensing Ion ChannelsIBA 09/2008
1	DiureticsIBA 09/2008
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 09/2008
1	Amiloride (Midamor)FDA LinkGeneric 09/2008
1	Ligand-Gated Ion ChannelsIBA 06/2008
1	ImmunophilinsIBA 07/2007
1	Antidepressive Agents (Antidepressants)IBA 06/2007
1	Analgesics (Analgesic Drugs)IBA 05/2007
1	Cyclic NucleotidesIBA 05/2007
1	Loperamide (Imodium)FDA LinkGeneric 05/2007
1	Hyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsIBA 05/2007
1	Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)IBA 03/2006
1	Appetite Depressants (Anorectics)IBA 02/2006
1	Aripiprazole (Abilify)FDA Link 02/2006
1	Dopamine (Intropin)FDA LinkGeneric 02/2006
1	Excitatory Amino AcidsIBA 02/2006
1	Carrier Proteins (Binding Protein)IBA 02/2006
1	3- aminotricyclo(2.2.1.02.6)heptane- 1,3- dicarboxylic acidIBA 06/2005
1	benzyloxyaspartate (TBOA)IBA 06/2005
1	Membrane Proteins (Integral Membrane Proteins)IBA 11/2004
1	Superoxide DismutaseIBA 03/2003
1	Riluzole FDA LinkGeneric 03/2003

Therapy/Procedure

4	Therapeutics 01/2017 - 01/2012